Insulin regulates aging and oxidative stress in Anopheles stephensi
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چکیده
منابع مشابه
Insulin regulates aging and oxidative stress in Anopheles stephensi.
Observations from nematodes to mammals indicate that insulin/insulin-like growth factor signaling (IIS) regulates lifespan. As in other organisms, IIS is conserved in mosquitoes and signaling occurs in multiple tissues. During bloodfeeding, mosquitoes ingest human insulin. This simple observation suggested that exogenous insulin could mimic the endogenous hormonal control of aging in mosquitoes...
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Insulin and insulin-like growth factor signaling (IIS) regulates cell death, repair, autophagy, and renewal in response to stress, damage, and pathogen challenge. Therefore, IIS is fundamental to lifespan and disease resistance. Previously, we showed that insulin-like growth factor 1 (IGF1) within a physiologically relevant range (0.013-0.13 µM) in human blood reduced development of the human p...
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Ookinete invasion of Anopheles midgut is a critical step for malaria transmission; the parasite numbers drop drastically and practically reach a minimum during the parasite's whole life cycle. At this stage, the parasite as well as the vector undergoes immense oxidative stress. Thereafter, the vector undergoes oxidative stress at different time points as the parasite invades its tissues during ...
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The scientific establishment has been discussing the relationship between aging and oxidative stress for quite some time now. While we are still far from a general agreement about this subject, there is an impressive amount of data collected that can be used to draw a compelling picture of the events that take place during the human aging process and their correlation with the oxidant status of...
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-----------------------------------------------------------------------------------------------3 Introduction--------------------------------------------------------------------------------------------4 Main text: Reactive oxygen species ----------------------------------------------------------------------4 Antioxidant defenses-------------------------------------------------------------------...
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ژورنال
عنوان ژورنال: Journal of Experimental Biology
سال: 2008
ISSN: 1477-9145,0022-0949
DOI: 10.1242/jeb.012955